Dizocilpine-derived K2060 exhibits enhanced blockage at NMDA receptors with impaired Mg2+ block and provides strong protection against audiogenic seizures
Marharyta Kolcheva, Jakub Netolický, Anna Misiachna, Natalia Rybalko, Petra Zahumenska, Jovana Doderovic, Alena Pakhomova, Claudia Valentina De Sanctis, Gregory Klein Schneider, Katarína Hemelíková, Kristyna Rehakova, Štěpán Kortus, Rostislav Tureček, Jan Korábečný, Ondrej Soukup, , Martin Hořák
This study evaluates how impaired Mg2+ block at NMDA receptors affects the efficacy of K2060, memantine, and ketamine in protecting against audiogenic seizures.
bioRxiv · Oct 13, 2026 · PreprintNeuroscience