Author

Kristyna Rehakova

Czech Academy of Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Organism:human· 1 Organism:mouse· 1 Organism:rat· 1

Frequent Co-Authors

Anna MisiachnaiD· 3 shared Jakub NetolickýiD· 3 shared Katarína HemelíkováiD· 3 shared Marek LadislaviD· 3 shared Marharyta KolchevaiD· 3 shared Martin HořákiD· 3 shared Petra ZahumenskaiD· 3 shared Štěpán KortusiD· 3 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Anna MisiachnaORCID

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Author profile →

3 papers

Recent·Most cited

Dizocilpine-derived K2060 exhibits enhanced blockage at NMDA receptors with impaired Mg2+ block and provides strong protection against audiogenic seizures

Marharyta Kolcheva, Jakub Netolický, Anna Misiachna, Natalia Rybalko, Petra Zahumenska, Jovana Doderovic, Alena Pakhomova, Claudia Valentina De Sanctis, Gregory Klein Schneider, Katarína Hemelíková, Kristyna Rehakova, Štěpán Kortus, Rostislav Tureček, Jan Korábečný, Ondrej Soukup, , Martin Hořák

This study evaluates how impaired Mg2+ block at NMDA receptors affects the efficacy of K2060, memantine, and ketamine in protecting against audiogenic seizures.

bioRxiv · Oct 13, 2026 · PreprintNeuroscience

The role of disulfide bonds in the GluN1 subunit in the early trafficking and functional properties of GluN1/GluN2 and GluN1/GluN3 NMDA receptors

Jakub Netolický, Seungha Lee, Petra Zahumenska, Marharyta Kolcheva, Anna Misiachna, Kristyna Rehakova, Štěpán Kortus, Jae‐man Song, Katarína Hemelíková, Emily Langore, Jovana Doderovic, Marek Ladislav, Young Ho Suh, Martin Hořák

This study investigates the role of disulfide bonds in the GluN1 subunit of NMDA receptors, showing their impact on trafficking and function, and introduces a method for synchronized release of NMDARs from the endoplasmic reticulum.

Journal of Neuroscience · Feb 24, 2026Peer-reviewedNeuroscience

Independent regulation of early trafficking of NMDA receptors by ligand-binding domains of the GluN1 and GluN2A subunits

Jakub Netolický, Petra Zahumenska, Anna Misiachna, Marharyta Kolcheva, Tomas Kucera, Jakub Fibigar, Kristyna Rehakova, Katarína Hemelíková, Štěpán Kortus, Emily Langore, Marek Ladislav, Jan Korábečný, Martin Hořák

This study shows that structural changes in the ligand-binding domains of GluN1 and GluN2A subunits independently regulate early trafficking of NMDARs and that surface expression does not always correlate with agonist sensitivity.

bioRxiv · Feb 2, 2024 · PreprintNeuroscience