Author
The Institute of Scientific and Industrial Research, The University of OsakaORCID 0000-0002-1705-5265Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Terence Gall-Duncan, Sangyoon Y. Ko, Isabelle K. Quick…·Christopher E. Pearson
This study shows that reducing somatic CAG expansions in HD mice improves motor function and disease markers, suggesting therapeutic potential for HD and similar repeat expansion diseases.
Leszek Błaszczyk, Marcin Ryczek, Bimolendu Das…·Agnieszka Kiliszek
This study determines the crystal structure of antisense C9orf72 hexanucleotide repeat RNA with and without a ligand, revealing its triplex-like structure and ligand binding mechanism.
Yuzo Fujino, Morio Ueyama, Taro Ishiguro…·Yoshitaka Nagai
This study shows FUS suppresses RAN translation by modulating G-quadruplex structure of GGGGCC repeat RNA, reducing neurodegeneration in C9-ALS/FTD model flies.
Amit Laxmikant Deshmukh, Marie‐Christine Caron, Mohiuddin Mohiuddin…·Christopher E. Pearson
The paper shows FAN1 nuclease processes and pauses on slipped-DNA repeats, reducing repeat expansions and delaying disease onset.