Author

Natasha M. Buchanan

Novartis (Switzerland)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:imaging· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1

Frequent Co-Authors

Ganesh PrasannaiD· 2 shared Garrett Klokman· 2 shared Junzheng YangiD· 2 shared Magali Saint‐GenieziD· 2 shared Michael TwarogiD· 2 shared Yubin Qiu· 2 shared Aaron D. DanilackiD· 1 shared Angela BanksiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Ganesh PrasannaORCID

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3 papers

Recent·Most cited

Identification of cellular and molecular risk signatures for progression to late-stage age-related macular degeneration using the 9-step Minnesota Grading System

Chia Ling Huang, Yubin Qiu, John T. Demirs, Xiaoqiu Wu, Michael Twarog, Omar Delgado, Maura A. Crowley, Natasha M. Buchanan, Nhi Vo, Lin Fan, Yanqun Wang, Junzheng Yang, Thomas R. Vollmer, Garrett Klokman, Sandra Jose, , Sha-Mei Liao

This study uses bulk RNA sequencing on postmortem human eye tissue to identify gene and pathway changes associated with progression from intermediate to late-stage AMD, highlighting potential therapeutic targets.

bioRxiv · Jul 10, 2025 · PreprintNeuroscience

A spontaneous mutation in ADIPOR1 causes retinal degeneration in mice

Junzheng Yang, Natasha M. Buchanan, Erika Urbano de Lima, Angela Banks, Valentin M. Sluch, Lin Fan, Barrett D. Leehy, Ivana A. Arellano, Yubin Qiu, Garrett Klokman, Shawn M. Hanks, Joanna Vrouvlianis, Vanessa Davis, Chung-Yeh Wu, Aaron D. Danilack, Dennis S. Rice

A mutation in AdipoR1 causes retinal degeneration in a subset of Cfh-/- mice, suggesting a genetic interaction between Cfh and AdipoR1.

bioRxiv · Jun 6, 2024 · PreprintNeuroscience

Use of machine learning for quantification of retinal pigment epithelium tight junctions improves assay sensitivity

Yan Gao, Mark‐Anthony Bray, Michael Twarog, YongYao Xu, Natasha M. Buchanan, Yiyun Zhang, Quintus G. Medley, Magali Saint‐Geniez, Ganesh Prasanna, Qin Zhang

This paper develops a machine learning method to quantify ZO-1 changes in RPE cells, improving assay sensitivity for detecting TJ aberrations in AMD-related treatments.

bioRxiv · May 24, 2024 · PreprintBioinformatics