Author

John T. Demirs

Novartis (Switzerland)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Neuroscience· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Assay:proteomics· 1

Frequent Co-Authors

Christopher W. WilsoniD· 3 shared Chia Ling HuangiD· 2 shared Cynthia L. GrosskreutziD· 2 shared Ganesh PrasannaiD· 2 shared Magali Saint‐GenieziD· 2 shared Sandra JoseiD· 2 shared Sha-Mei LiaoiD· 2 shared Yubin Qiu· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersNeuroscience

Christopher W. WilsonORCID

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Author profile →

3 papers

Recent·Most cited

Identification of cellular and molecular risk signatures for progression to late-stage age-related macular degeneration using the 9-step Minnesota Grading System

Chia Ling Huang, Yubin Qiu, John T. Demirs, Xiaoqiu Wu, Michael Twarog, Omar Delgado, Maura A. Crowley, Natasha M. Buchanan, Nhi Vo, Lin Fan, Yanqun Wang, Junzheng Yang, Thomas R. Vollmer, Garrett Klokman, Sandra Jose, , Sha-Mei Liao

This study uses bulk RNA sequencing on postmortem human eye tissue to identify gene and pathway changes associated with progression from intermediate to late-stage AMD, highlighting potential therapeutic targets.

bioRxiv · Jul 10, 2025 · PreprintNeuroscience

Multiparametric grading of glaucoma severity by histopathology can enable post-mortem substratification of disease state

Chuanxi Xiang, VijayKrishna Raghunathan, Yubin Qiu, Manisha N. Mehta, John T. Demirs, Cynthia L. Grosskreutz, Christopher W. Wilson, Ganesh Prasanna

This paper introduces a multiparametric grading system to stratify post-mortem glaucoma tissue by disease severity using structural and molecular markers.

Acta Neuropathologica Communications · Jan 6, 2025Peer-reviewedPathology

APOE Impacts Lipid Trafficking in Retinal Pigment Epithelium Cells

Sarah E. V. Richards, John T. Demirs, Sandra Jose, Lin Fan, YongYao Xu, Robert Esterberg, Chia Ling Huang, Christopher W. Wilson, Magali Saint‐Geniez, Sha-Mei Liao

This study investigates how APOE variants affect lipid trafficking in RPE cells, finding that APOE knockout and APOE2-expressing cells show lipid transport deficits, while APOE4-expressing cells upregulate APOE in response to lipid challenges.

bioRxiv · May 30, 2024 · PreprintCell Biology