Magali Saint‐Geniez

OSK factors rejuvenate aged RPE cells by activating a Tet2-independent oxidative resilience pathway through GSTA4, restoring vision and reversing age-related degeneration.

This study shows dsRNA triggers RIG-I signaling, leading to inflammation and RPE degeneration in AMD, with implications for pathogenesis.

This study uses bulk RNA sequencing on postmortem human eye tissue to identify gene and pathway changes associated with progression from intermediate to late-stage AMD, highlighting potential therapeutic targets.

This study shows that deleting endomucin in endothelial cells causes structural and functional issues in kidney glomeruli, including podocyte damage and albuminuria.

This study investigates how APOE variants affect lipid trafficking in RPE cells, finding that APOE knockout and APOE2-expressing cells show lipid transport deficits, while APOE4-expressing cells upregulate APOE in response to lipid challenges.

This study shows that blocking P2Y receptors with suramin prevents stress-induced RPE and photoreceptor degeneration in vitro and in a zebrafish model.

This paper develops a machine learning method to quantify ZO-1 changes in RPE cells, improving assay sensitivity for detecting TJ aberrations in AMD-related treatments.