Piezo1 is required for outflow tract and aortic valve development.
Adèle Faucherre, Hamid Moha ou Maati, Nathalie Nasr, Amélie Pinard, Alexis Théron, Gaëlle Odelin, Jean‐Pierre Desvignes, David Salgado, Gwenaëlle Collod‐Béroud, Jean-François Aviérinos, Guillaume Lebon, Stéphane Zaffran, Chris Jopling
This study shows that PIEZO1 is essential for outflow tract and aortic valve development in zebrafish and identifies PIEZO1 variants linked to bicuspid aortic valve in humans.
bioRxiv · Jan 23, 2019Developmental Biology