Rewired m6A methylation of promoter antisense RNAs in Alzheimer disease regulates global gene transcription in the 3D nucleome
Benxia Hu, Yuqiang Shi, Feng Xiong, Yi-Ting Chen, Xiaoyu Zhu, Elisa Cristina Carrillo, Xingzhao Wen, Nathan A. Drolet, Chetan Singh Rajpurohit, Xiangmin Xu, Dung‐Fang Lee, Claudio A. Soto, Sheng Zhong, Vasanthi Jayaraman, Hui Zheng, Wenbo Li
The paper identifies AD-associated changes in m6A methylation on promoter antisense RNAs and shows their role in regulating gene expression and neuronal survival in Alzheimer's disease.
bioRxiv · Mar 22, 2025 · PreprintMolecular Biology