MCT1 activity defines an aggressive metabolic phenotype and therapeutic target in non-small cell lung cancer
Robert B Cameron, Kristen Erika Shema, Nathan Dubois, Maia G. Clare, Nia G. Hammond, Mayher Kaur, Brianna K. Chang, Elyse G. Schechter, Juliya Hsiang, Zuzanna Marczenia, Marina C. Garassino, Ling Cai, Christine M. Bestvina, Thomas P. Mathews, Alpaslan Tasdogan, , Brandon Faubert
This study shows that MCT1-mediated lactate uptake sustains nucleotide homeostasis in NSCLC, and its inhibition enhances chemotherapy efficacy by exposing a metabolic vulnerability.
bioRxiv · Sep 22, 2026 · PreprintCancer Biology