Author

Nathan F. Chiappa

Georgia Institute of Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:metabolomics· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Edward A. BotchweyiD· 3 shared Daniel C. ShahiD· 2 shared Hongmanlin ZhangiD· 2 shared Krishnendu RoyiD· 2 shared Nidhi LaliD· 2 shared S’Dravious A. DeVeauxiD· 2 shared Young Charles JangiD· 2 shared Afra I. TomaiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersBioengineering

Edward A. BotchweyORCID

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Author profile →

3 papers

Recent·Most cited

Exogenous Sphingomyelinase Mediates MSC-derived EV Biogenesis and Enhances Potency via Repackaging of Molecular Cargo

Daniel C. Shah, S’Dravious A. DeVeaux, Hongmanlin Zhang, Alan Y. Liu, Tosin A. Adedipe, Nathan F. Chiappa, Afra I. Toma, Krishna A. Patel, Young Charles Jang, Steven L. Goudy, Todd Sulchek, Krishnendu Roy, Edward A. Botchwey

The paper shows that exogenous sphingomyelinase increases MSC-derived EV yield and alters their cargo, enhancing therapeutic effects in a murine wound model.

iScience · Feb 11, 2026Peer-reviewedBioengineering

Resolving vs. Non-resolving Sphingolipid Dynamics During Macrophage Activation: A Time-resolved Metabolic Analysis

Nathan F. Chiappa, Nidhi Lal, Edward A. Botchwey

This study maps sphingolipid dynamics in macrophages during inflammation, identifying resolving and non-resolving metabolites and suggesting targeted therapeutic strategies.

Journal of Lipid Research · Sep 16, 2025Peer-reviewedImmunology

Sphingomyelinase Licensing of Mesenchymal Stromal Cells Alters Lipid and Protein Metabolites for Immunomodulation

S’Dravious A. DeVeaux, Daniel C. Shah, Kejie Rui, Nathan F. Chiappa, Hongmanlin Zhang, Nidhi Lal, Rhyland O’Neill, Young Charles Jang, Luke J. Mortensen, Krishnendu Roy, Edward A. Botchwey

This study shows that sphingomyelinase treatment alters lipid and protein metabolites in MSCs, enhancing their immunomodulatory properties similar to cytokine-based priming.

bioRxiv · Jul 17, 2025 · PreprintBioengineering