Steven L. Goudy

Exogenous Sphingomyelinase Mediates MSC-derived EV Biogenesis and Enhances Potency via Repackaging of Molecular Cargo

The paper shows that exogenous sphingomyelinase increases MSC-derived EV yield and alters their cargo, enhancing therapeutic effects in a murine wound model.

Delivery of A Jagged1-PEG-MAL hydrogel with Pediatric Human Bone Cells Regenerates Critically-Sized Craniofacial Bone Defects

This study investigates JAG1 delivery with pediatric human osteoblasts as a bone regenerative therapy for craniofacial defects in a murine model.

Spatial Morphoproteomic Features Predict Uniqueness of Immune Microarchitectures and Responses in Lymphoid Follicles

The paper introduces SNOWFLAKE, a graph neural network framework that predicts disease status from multiplex imaging data in human B-cell follicles, showing improved performance over other methods.

JAGGED1 Stimulates Cranial Neural Crest Cell Osteoblast Commitment Pathways and Bone Regeneration Independent of Canonical NOTCH Signaling

This study shows JAG1 promotes bone regeneration in mice by activating osteogenic pathways in cranial neural crest cells, independent of canonical NOTCH signaling.

A non-canonical JAGGED1 signal to JAK2 mediates osteoblast commitment in cranial neural crest cells

This study identifies a non-canonical JAG1 signal to JAK2 pathway that mediates osteoblast commitment in cranial neural crest cells, independent of the canonical NOTCH pathway.