Young Charles Jang

Exogenous Sphingomyelinase Mediates MSC-derived EV Biogenesis and Enhances Potency via Repackaging of Molecular Cargo

The paper shows that exogenous sphingomyelinase increases MSC-derived EV yield and alters their cargo, enhancing therapeutic effects in a murine wound model.

Neat1 alleviates ischemic injury in skeletal muscles

This study identifies Neat1 as a regulator of hypoxic response in aged skeletal muscle, showing that its overexpression protects against ischemic injury in a murine model.

Sphingomyelinase Licensing of Mesenchymal Stromal Cells Alters Lipid and Protein Metabolites for Immunomodulation

This study shows that sphingomyelinase treatment alters lipid and protein metabolites in MSCs, enhancing their immunomodulatory properties similar to cytokine-based priming.

Aberrant Fibro-Adipogenic Progenitor Subpopulations Drive Volumetric Muscle Loss-Induced Fibrosis

This study identifies an aberrant FAP subpopulation in VML that drives fibrosis and presents potential targets for scarless muscle regeneration.

Improving Functional Muscle Regeneration in Volumetric Muscle Loss Injuries by Shifting the Balance of Inflammatory and Pro-Resolving Lipid Mediators

This study shows that delivering a stable isomer of Resolvin D1 via a hydrogel improves muscle regeneration and reduces inflammation in volumetric muscle loss injuries.

Comparison of neuromuscular junction dynamics following ischemic and aged skeletal muscle

This study compares neuromuscular junction dynamics in aged and ischemic skeletal muscle, finding similar degeneration patterns in both conditions.