Targeting Interferon-Driven Inflammatory Memory Prevents Epigenetic Evolution of Cancer Immunotherapy Resistance
Jingya Qiu, Darwin Ye, Xinyi E. Chen, Nathan J Dangle, Benjamin Yoshor, Thomas Zhang, Yue Shao, Vamshidhar C. Nallamala, Shangshang Wang, Diqiu Ren, Yuanming Xu, Jie Chen, Nancy Ruonan Zhang, Junwei Shi, Roger A. Greenberg, Andy J. Minn
This study identifies inflammatory memory as a mechanism for cancer resistance to immunotherapy and shows that combining JAK and TBK1 inhibitors can prevent it.
bioRxiv · Aug 13, 2024 · PreprintImmunology