Andy J. Minn

The paper identifies an inflammatory secretory progenitor cell state in Crohn's disease patients and shows its epigenetic regulation in stem cells.

This study shows TLR priming increases NLRC4 expression in murine macrophages, enabling detection of immunoevasive NAIP ligands, while human macrophages lack this response.

FLASH proton radiotherapy improves normal tissue toxicity without compromising anti-tumor efficacy by coordinating IFN-I signaling across stromal, immune, and revSC networks.

This study identifies inflammatory memory as a mechanism for cancer resistance to immunotherapy and shows that combining JAK and TBK1 inhibitors can prevent it.

This paper introduces CellANOVA, a statistical model to recover biological signals lost during single-cell data integration by distinguishing batch effects from true biological variation.

This study shows that RUNX1 in granulocyte-monocyte progenitors limits neutrophil inflammatory cytokine production by restricting retrotransposon chromatin accessibility and type I interferon signaling.

DENDRO profiles genetic heterogeneity in scRNA-seq data by detecting subclones, assigning cells to subclones, and reconstructing phylogenetic trees.