Author

Jie Chen

Harvard UniversityORCID 0000-0002-2852-3618Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Jie Chen15 papers · Nanjing Agricultural University

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Adam P. JonesiD· 2 shared Alona MuzikanskyiD· 2 shared Bingyu Xiu· 2 shared Konstantina M. StankovićiD· 2 shared Lei XuiD· 2 shared Limeng WuiD· 2 shared Lukas David LandeggeriD· 2 shared Scott Randall PlotkiniD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Adam P. JonesORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Enhanced Tumor Control and Hearing Loss Prevention Achieved with Combined Immune Checkpoint Inhibitor and Anti-VEGF Therapy in Vestibular Schwannoma Model

Simeng Lu, Zhenzhen Yin, Limeng Wu, Yao Sun, Jie Chen, Lai Man Natalie Wu, Janet L. Oblinger, Day Caven Blake, Bingyu Xiu, Lukas David Landegger, Richard Seist, William W. Ho, Adam P. Jones, Alona Muzikansky, Konstantina M. Stanković, , Lei Xu

Nature Communications · Feb 11, 2026Peer-reviewedCancer Biology

Zinc availability in the tumor microenvironment dictates anti-PD1 response in CDKN2ALow tumors via increased macrophage phagocytosis

Raquel Buj, Aidan R. Cole, Jeff Danielson, Jimmy P. Xu, Drew E. Hurd, Akash Kishore, Katarzyna M. Kedziora, Jie Chen, Baixue Yang, David Barras, Apoorva Uboveja, Amandine Amalric, Juan J Apiz Saab, Jayamanna M. Wickramasinghe, Naveen Kumar Tangudu, , Katherine M. Aird

This study shows that zinc availability in the tumor microenvironment affects anti-PD1 therapy response in CDKN2A-low tumors through macrophage phagocytosis.

bioRxiv · Feb 8, 2025 · PreprintCancer Biology

Direct and abscopal anti-tumor responses elicited by peripheral nerve schwannoma irradiation synergize with anti-PD1 treatment in vestibular schwannoma models

Zhenzhen Yin, Simeng Lu, Limeng Wu, Yao Sun, David W. Blake, Jie Chen, Lukas David Landegger, William W. Ho, Bingyu Xiu, Adam P. Jones, Alona Muzikansky, Helen Alice Shih, Konstantina M. Stanković, Scott Randall Plotkin, Lei Xu

This study shows that combining anti-PD1 treatment with radiation therapy for vestibular schwannomas improves tumor control, reduces radiation dose, and elicits systemic anti-tumor effects.

bioRxiv · Dec 29, 2024 · PreprintCancer Biology

Targeting Interferon-Driven Inflammatory Memory Prevents Epigenetic Evolution of Cancer Immunotherapy Resistance

Jingya Qiu, Darwin Ye, Xinyi E. Chen, Nathan J Dangle, Benjamin Yoshor, Thomas Zhang, Yue Shao, Vamshidhar C. Nallamala, Shangshang Wang, Diqiu Ren, Yuanming Xu, Jie Chen, Nancy Ruonan Zhang, Junwei Shi, Roger A. Greenberg, Andy J. Minn

This study identifies inflammatory memory as a mechanism for cancer resistance to immunotherapy and shows that combining JAK and TBK1 inhibitors can prevent it.

bioRxiv · Aug 13, 2024 · PreprintImmunology