Genomic imprinting of the metabolic regulator gene Klf14 is regulated by a paternal sub-TAD anchored at Mest and a shared enhancer in mice.
Amanda Ha, Natsuki Hayashi, Aaron Bogutz, Benoît Moindrot, Laura Gómez, Juliette Harris, Alexandre Marcil, Franck Court, Miyuki Shindo, Philippe Arnaúd, Jacques Drouin, Thierry Forné, Daan Noordermeer, Shuji Takada, Kazuhiko Nakabayashi, Louis Lefebvre
This paper identifies a paternal sub-TAD and shared enhancer that regulate Klf14 genomic imprinting in mice, revealing a mechanism involving Mest and allele-specific CTCF binding.
bioRxiv · May 13, 2026 · PreprintDevelopmental Biology