Author

Shuji Takada

National Research Institute for Child Health and DevelopmentORCID 0000-0002-9406-4683Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Research Focus:differential expression· 3 Assay:DNA methylation· 3 Research Focus:gene regulatory network inference· 3 Organism:mouse· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Organism:rat· 1

Frequent Co-Authors

Kazuhiko NakabayashiiD· 2 shared Aaron Bogutz· 1 shared Alexandre Marcil· 1 shared Amanda Ha· 1 shared Ana MonteagudoiD· 1 shared Asuka Miura· 1 shared Azusa InoueiD· 1 shared Benoît MoindrotiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersDevelopmental Biology

Kazuhiko NakabayashiORCID

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4 papers

Recent·Most cited

Genomic imprinting of the metabolic regulator gene Klf14 is regulated by a paternal sub-TAD anchored at Mest and a shared enhancer in mice.

Amanda Ha, Natsuki Hayashi, Aaron Bogutz, Benoît Moindrot, Laura Gómez, Juliette Harris, Alexandre Marcil, Franck Court, Miyuki Shindo, Philippe Arnaúd, Jacques Drouin, Thierry Forné, Daan Noordermeer, Shuji Takada, Kazuhiko Nakabayashi, Louis Lefebvre

This paper identifies a paternal sub-TAD and shared enhancer that regulate Klf14 genomic imprinting in mice, revealing a mechanism involving Mest and allele-specific CTCF binding.

bioRxiv · May 13, 2026 · PreprintDevelopmental Biology

Conservation and divergence of canonical and non-canonical imprinting in murids

Julien Richard Albert, Toshihiro Kobayashi, Azusa Inoue, Ana Monteagudo, Soichiro Kumamoto, Tomoya Takashima, Asuka Miura, Mami Oikawa, Fumihito Miura, Shuji Takada, Masumi Hirabayashi, Keegan D. Korthauer, Kazuki Kurimoto, Max Greenberg, Matthew C. Lorincz, Hisato Kobayashi

The paper identifies imprinted genes in rat tissues, finds conservation of canonical imprints in embryos but divergence in extra-embryonic tissues, and discovers novel non-canonical imprints.

Genome biology · Mar 14, 2023Peer-reviewedGenomics

DNA methylation signature in NSD2 loss-of-function variants appeared similar to that in Wolf-Hirschhorn syndrome

Tomoko Kawai, Shiori Kinoshita, Yuka Takayama, Eriko Onishi, Hiromi Kamura, Kazuaki Kojima, Hiroki Kikuchi, Miho Terao, Tohru Sugawara, Ohsuke Migita, Masayo Kagami, Tsuyoshi Isojima, Yu Yamaguchi, Keiko Wakui, Hirofumi Ohashi, , Kenichiro Hata

The paper identifies DNA methylation signatures associated with NSD2 loss-of-function variants and shows their similarity to those in Wolf-Hirschhorn syndrome.

bioRxiv · Jan 6, 2023 · PreprintGenetics

Lin28a/let-7 Pathway Modulates the Hox Code via Polycomb Regulation during Axial Patterning in Vertebrates

Tempei Sato, Kensuke Kataoka, Yoshiaki Ito, Shigetoshi Yokoyama, Masafumi Inui, Masaki Mori, Satoru Takahashi, Keiichi Akita, Shuji Takada, Hiroe Ueno-Kudoh, Hiroshi Asahara

This study shows the Lin28a/let-7 pathway regulates Hox gene expression during axial patterning by modulating Polycomb complex occupancy in vertebrates.

eLife · May 29, 2020Peer-reviewedDevelopmental Biology