Louis Lefebvre

The paper investigates the regulation of maternal allele bias in Copg2 during neurogenesis, showing it involves a two-step mechanism beyond MestXL-mediated interference.

This paper identifies a paternal sub-TAD and shared enhancer that regulate Klf14 genomic imprinting in mice, revealing a mechanism involving Mest and allele-specific CTCF binding.

This paper uses long-read DNA methylation sequencing and Strand-seq to detect parent-of-origin and haplotype chromosomes, achieving high accuracy in five trios.

The paper shows that lineage-specific retroviral promoters drive the evolution of maternal imprinting by establishing DNA methylation at imprinted genes in mice and humans.