GDF15 reprograms the microenvironment to drive the development of uveal melanoma liver metastases
Sathya Neelature Sriramareddy, Navya Siddarajappa, Jun Sung Park, Thanh Nguyen, Jeffim N. Kuznetsoff, Stefan Kurtenbach, James Jarad Dollar, David Adams, Jonathan D. Licht, Zélia M. Corrêa, Y. Ann Chen, J. William Harbour, Keiran S.M. Smalley
This study identifies GDF15 as a driver of uveal melanoma liver metastasis by reprogramming hepatic stellate cells to promote angiogenesis and matrix deposition.
bioRxiv · May 7, 2025 · PreprintCancer Biology