Cancer BiologybioRxivPreprint
A multi-step immune-competent genetic mouse model reveals phenotypic plasticity in uveal melanoma
Xiaonan Xu, Xiaoxian Liu, James Jarad Dollar…·Florian A. Karreth
This paper develops a genetically engineered mouse model of uveal melanoma that recapitulates human disease progression and immune microenvironment features, revealing phenotypic plasticity and cooperative genetic drivers.