Lysosomes cell autonomously regulate myeloid cell states and immune responses
Leon Tejwani, Catherine M Heffner, Christopher D. Balak, Lukas L. Skuja, David Tatarakis, Anil Rana, Seungyoon B. Yu, Gabriel A. Fitzgerald, Connie Ha, Gabrielly Lunkes de Melo, Elizabeth Wen Sun, Matthew J. Simon, Jason C. Dugas, Johann Chow, Elliot R. Thomsen, , Gilbert Di Paolo
This study shows lysosomal health influences myeloid cell states and immune responses, with Grn deficiency leading to lysosomal dysfunction and specific transcriptional changes in microglia.
Immunity · Aug 1, 2026Peer-reviewedNeuroscience