David Tatarakis

This study shows lysosomal health influences myeloid cell states and immune responses, with Grn deficiency leading to lysosomal dysfunction and specific transcriptional changes in microglia.

This study shows chronic NLRP3 inflammasome activation leads to neutrophil entry into the brain and interactions with microglia, contributing to CNS pathology.

The paper identifies a Wnt signaling to Sox2 ratio that predicts neuromesodermal fate potential in zebrafish and shows Sox2's role in maintaining progenitor states.

This study shows that GPR34 regulates microglia function and loss-of-function in TREM2 KO microglia rescues cholesterol metabolism, suggesting GPR34 as a therapeutic target for Alzheimer's disease.

This study compares the biodistribution of Fc-engineered molecules targeting BBB receptors with standard antibodies, showing distinct CNS and peripheral organ targeting.

The paper shows that mutations in cohesin subunits rad21 and stag2b have distinct developmental effects in zebrafish, suggesting independent roles of cohesin quantity and composition in early development.

This paper demonstrates that systemically delivered OTV, a TfR-binding molecule, effectively transports ASO across the BBB, achieving widespread and sustained knockdown of target genes in the CNS of mice and non-human primates.

This study identifies Lmo7a as a regulator of neural crest cell migration and lineage specification by modulating cell adhesion and Wnt signaling.