Author

Gabriel A. Fitzgerald

Denali Therapeutics (United States)ORCID 0000-0002-8235-0148Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

Connie HaiD· 2 shared Elizabeth Wen SuniD· 2 shared Thomas SandmanniD· 2 shared Anil RanaiD· 1 shared Anthony A. EstradaiD· 1 shared Benjamin J. HuffmaniD· 1 shared Brian M. Fox· 1 shared Catherine M HeffneriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Connie HaORCID

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Author profile →

2 papers

Recent·Most cited

Lysosomes cell autonomously regulate myeloid cell states and immune responses

Leon Tejwani, Catherine M Heffner, Christopher D. Balak, Lukas L. Skuja, David Tatarakis, Anil Rana, Seungyoon B. Yu, Gabriel A. Fitzgerald, Connie Ha, Gabrielly Lunkes de Melo, Elizabeth Wen Sun, Matthew J. Simon, Jason C. Dugas, Johann Chow, Elliot R. Thomsen, , Gilbert Di Paolo

This study shows lysosomal health influences myeloid cell states and immune responses, with Grn deficiency leading to lysosomal dysfunction and specific transcriptional changes in microglia.

Immunity · Aug 1, 2026Peer-reviewedNeuroscience

CNS-penetrant NLRP3 inhibitor achieves durable weight loss and reverses hypothalamic inflammation in diet-induced obesity

Jing Guo, Tomás P. Bachor, Ryan Takahashi, Micah Steffek, Gabriel A. Fitzgerald, Benjamin J. Huffman, Dylan Braun, Suk Ji Han, Thomas Sandmann, Connie Ha, Katrina W. Lexa, Yun-Ting Hsieh, Maayan R. Agam, Elizabeth Wen Sun, Xiang Wang, , Ernie Yulyaningsih

TN-783, a CNS-penetrant NLRP3 inhibitor, induces sustained weight loss and reverses hypothalamic inflammation in diet-induced obese mice.

bioRxiv · Oct 6, 2025 · PreprintNeuroscience