Author

Lukas L. Skuja

Denali Therapeutics (United States)ORCID 0000-0001-9675-2685Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

Connie HaiD· 2 shared David TatarakisiD· 2 shared Elizabeth Wen SuniD· 2 shared Gilbert Di PaoloiD· 2 shared Jason C. DugasiD· 2 shared Jung H. SuhiD· 2 shared Lily SarrafhaiD· 2 shared Thomas SandmanniD· 2 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Connie HaORCID

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2 papers

Recent·Most cited

Lysosomes cell autonomously regulate myeloid cell states and immune responses

Leon Tejwani, Catherine M Heffner, Christopher D. Balak, Lukas L. Skuja, David Tatarakis, Anil Rana, Seungyoon B. Yu, Gabriel A. Fitzgerald, Connie Ha, Gabrielly Lunkes de Melo, Elizabeth Wen Sun, Matthew J. Simon, Jason C. Dugas, Johann Chow, Elliot R. Thomsen, , Gilbert Di Paolo

This study shows lysosomal health influences myeloid cell states and immune responses, with Grn deficiency leading to lysosomal dysfunction and specific transcriptional changes in microglia.

Immunity · Aug 1, 2026Peer-reviewedNeuroscience

Chronic NLRP3 inflammasome activation drives neutrophil brain entry and interactions with microglia

Lukas L. Skuja, Sophia M. Guldberg, David A. Joy, Jason C. Dugas, Neal S. Gould, Roni Chau, David Tatarakis, Isabel A. Becerra, Cynthia Chau, Connie Ha, David Huynh, Hoang Ngan Nguyen, Lily Sarrafha, Elizabeth Wen Sun, Shan V. Andrews, , Gilbert Di Paolo

This study shows chronic NLRP3 inflammasome activation leads to neutrophil entry into the brain and interactions with microglia, contributing to CNS pathology.

bioRxiv · Apr 23, 2026 · PreprintNeuroscience