Author

Catherine M Heffner

Denali Therapeutics (United States)ORCID 0000-0003-3631-5242Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Adrian M. IsaacsiD· 1 shared Anil RanaiD· 1 shared Christopher D. BalakiD· 1 shared Christopher K. GlassiD· 1 shared Connie HaiD· 1 shared David TatarakisiD· 1 shared Elizabeth Wen SuniD· 1 shared Elliot R. ThomseniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperCell Biology

Adrian M. IsaacsORCID

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2 papers

Recent·Most cited

NeuroscienceImmunityPeer-reviewedAug 1, 2026

Lysosomes cell autonomously regulate myeloid cell states and immune responses

Leon Tejwani, Catherine M Heffner, Christopher D. Balak…·Gilbert Di Paolo

This study shows lysosomal health influences myeloid cell states and immune responses, with Grn deficiency leading to lysosomal dysfunction and specific transcriptional changes in microglia.

5 citationstop 1%

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Cell BiologyDevelopmental CellPeer-reviewedJun 25, 2026

The ALS- and FTD-associated proteins Annexin A11 and CHMP2B act sequentially in membrane repair

Catherine M Heffner, Georgina P. Starling, Lorian Cobra Straker…·Jeremy Graham Carlton

The paper investigates the sequential roles of Annexin A11 and CHMP2B in membrane repair, showing Annexins act first to seal damage while ESCRT-III removes damaged membranes.

5 citationstop 2%

experimental assaycell signaling & trafficking

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