Long term rescue of Alzheimer deficits in vivo by one-time gene-editing of App C-terminus.
Brent D. Aulston, Kirstan Gimse, Hannah Bazick, Enikö A. Kramár, Donald P. Pizzo, Farbod Shavarebi, Trinity Rust, Sheila Garcia Rosa, Leonardo A Parra‐Rivas, Jichao Sun, Kristen Branes‐Guerrero, Nidhi Checka, Neda Bagheri, Sara B. Rosenthal, Nihal Satyadev, , Subhojit Roy
The paper uses CRISPR-Cas9 to edit the App gene in mice, reducing Alzheimer's disease symptoms and showing long-term benefits.
bioRxiv · Jun 8, 2024 · PreprintNeuroscience