Anjon Audhya

In situ cryo-ET defines the ultrastructure of ER exit sites in human cells

The paper uses cryo-ET and fluorescence microscopy to study ER exit sites in human cells, revealing COPII and COPI vesicle structures and resolving their origin and organisation.

A privileged ER compartment for post-translational heteromeric assembly of an ion channel

The paper identifies a specialized ER compartment that sequesters hERG1b subunits, enabling post-translational heteromeric assembly with hERG1a instead of degradation.

Toxoplasma gondii infection accelerates the progression of hereditary spastic paraplegia

This study investigates how chronic Toxoplasma gondii infection affects neurodegenerative disease progression in a rat model of hereditary spastic paraplegia, finding exacerbated symptoms in infected rats.

Multiple roles for TFG ring complexes in neuronal cargo trafficking

This study identifies structural and functional roles of TFG ring complexes in neuronal cargo trafficking, showing how mutations disrupt their stability and contribute to neurodegenerative disease.

Long term rescue of Alzheimer deficits in vivo by one-time gene-editing of App C-terminus.

The paper uses CRISPR-Cas9 to edit the App gene in mice, reducing Alzheimer's disease symptoms and showing long-term benefits.

Defining Cardiac Nerve Architecture During Development, Disease, and Regeneration

The paper defines cardiac nerve architecture during development, disease, and regeneration using 3D modeling and imaging, showing regenerating myocardium reestablishes physiological innervation.

TES-1/Tes protects junctional actin networks under tension from self-injury during epidermal morphogenesis in the C. elegans embryo

This study identifies TES-1 as a protein that stabilizes junctional actin networks during cell shape changes in C. elegans embryos by preventing self-injury under tension.