Author

Kristen Branes‐Guerrero

Eli Lilly (United States)ORCID 0000-0002-2181-2425Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Organism:mouse· 1 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Brent D. AulstoniD· 2 shared Donald P. PizzoiD· 2 shared Leonardo A Parra‐RivasiD· 2 shared Subhojit RoyiD· 2 shared Anjon AudhyaiD· 1 shared David A. ScottiD· 1 shared Dube Dheeraj Prakashchand· 1 shared Enikö A. KramáriD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersNeuroscience

Brent D. AulstonORCID

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2 papers

Recent·Most cited

Long term rescue of Alzheimer deficits in vivo by one-time gene-editing of App C-terminus.

Brent D. Aulston, Kirstan Gimse, Hannah Bazick, Enikö A. Kramár, Donald P. Pizzo, Farbod Shavarebi, Trinity Rust, Sheila Garcia Rosa, Leonardo A Parra‐Rivas, Jichao Sun, Kristen Branes‐Guerrero, Nidhi Checka, Neda Bagheri, Sara B. Rosenthal, Nihal Satyadev, , Subhojit Roy

The paper uses CRISPR-Cas9 to edit the App gene in mice, reducing Alzheimer's disease symptoms and showing long-term benefits.

bioRxiv · Jun 8, 2024 · PreprintNeuroscience

Serine-129 phosphorylation of α-synuclein is a trigger for physiologic protein-protein interactions and synaptic function

Leonardo A Parra‐Rivas, Kayalvizhi Madhivanan, Brent D. Aulston, Lina Wang, Dube Dheeraj Prakashchand, Nicholas P. Boyer, Verônica Monteiro Saia-Cereda, Kristen Branes‐Guerrero, Donald P. Pizzo, Pritha Bagchi, V. S. Sundar, Yong Tang, Utpal Das, David A. Scott, Padmini Rangamani, , Subhojit Roy

This study shows that phosphorylation of α-synuclein at Serine-129 is a physiologic trigger for protein interactions and synaptic function, challenging its previous association with pathology.

Neuron · Dec 1, 2023Peer-reviewedNeuroscience