Myosin inhibitor reverses hypertrophic cardiomyopathy in pediatric iPSC-cardiomyocytes to mirror variant correction
Caroline Kinnear, Abdelrahman Said, Guoliang Meng, Yimu Zhao, Erika Yan Wang, Naimeh Rafatian, Neha Parmar, Wei Wei, Filio Billia, Craig A. Simmons, Milica Radisic, James Ellis, Seema R. Mital
This study shows that a myosin ATPase inhibitor reverses HCM phenotypes in pediatric iPSC-cardiomyocytes, with effects dependent on the underlying genetic variant.
Cell Reports Medicine · Apr 19, 2024Peer-reviewedGenetics