Author

Guoliang Meng

Hospital for Sick Children

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Developmental Biology· 1 Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Abdelrahman SaidiD· 2 shared Caroline KinneariD· 2 shared James EllisiD· 2 shared Seema R. MitaliD· 2 shared A. Orioli· 1 shared Adam P GiessiD· 1 shared Afshan SiddiqiD· 1 shared Alex Stuckey· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersGenetics

Abdelrahman SaidORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Myosin inhibitor reverses hypertrophic cardiomyopathy in pediatric iPSC-cardiomyocytes to mirror variant correction

Caroline Kinnear, Abdelrahman Said, Guoliang Meng, Yimu Zhao, Erika Yan Wang, Naimeh Rafatian, Neha Parmar, Wei Wei, Filio Billia, Craig A. Simmons, Milica Radisic, James Ellis, Seema R. Mital

This study shows that a myosin ATPase inhibitor reverses HCM phenotypes in pediatric iPSC-cardiomyocytes, with effects dependent on the underlying genetic variant.

Cell Reports Medicine · Apr 19, 2024Peer-reviewedGenetics

Whole genome sequencing delineates regulatory and novel genic variants in childhood cardiomyopathy

Robert Lesurf, Abdelrahman Said, Oyediran Akinrinade, Jeroen Breckpot, Kathleen Delfosse, Ting Liu, Roderick Yao, Gabrielle Persad, Fintan McKenna, Ramil R. Noche, Winona Oliveros, Kaia Mattioli, Shreya Shah, Anastasia Miron, Qian Yang, , R. Sultana

This study uses whole-genome sequencing to identify regulatory and novel genic variants contributing to childhood cardiomyopathy.

npj Genomic Medicine · Mar 14, 2022Peer-reviewedGenetic & Genomic Medicine

Control iPSC lines with clinically annotated genetic variants for versatile multi-lineage differentiation

Matthew R. Hildebrandt, Miriam S. Reuter, Wei Wei, Naeimeh Tayebi, Jiajie Liu, Sazia Sharmin, Jaap Mulder, Lee Stephen Lesperance, Patrick M. Brauer, Rebecca S.F. Mok, Caroline Kinnear, Alina Piekna, Asli Romm, Jennifer Howe, Peter Pasceri, , James Ellis

The paper describes the generation of genetically annotated iPSC lines from healthy donors and demonstrates their use in creating disease-relevant cell types and identifying variant-preferred lines for control in disease modeling.

Stem Cell Reports · Dec 1, 2019Peer-reviewedDevelopmental Biology