HIV-1 Tat favors the multiplication of Mycobacterium tuberculosis and toxoplasma by inhibiting clathrin-mediated endocytosis and autophagy
Aurélie Rivault, Audrey Bernut, Myriam Ben-Neji, Magali Abrantes, Maxime Jansen, Sylvaine Huc-Brandt, Sébastien Besteiro, Yann Bordat, Mai Nguyen Chi, Nelly Audemard, Margaux Mesleard-Roux, David Perrais, Olivier Neyrolles, Geanncarlo Lugo‐Villarino, Christel Vérollet, , Bruno D. Beaumelle
The paper shows HIV-1 Tat enhances Mtb and Toxoplasma growth by inhibiting clathrin-mediated endocytosis and autophagy through PI(4,5)P2 binding and palmitoylation.
PLoS Pathogens · Sep 11, 2025Peer-reviewedMicrobiology