Geanncarlo Lugo‐Villarino

This study uses dual human lung models to evaluate anti-tuberculosis drugs and host-directed therapies, revealing compartment-specific efficacy and immune responses.

This study shows that inhibiting glycolysis in TB-infected macrophages reduces HIV-1 spread by blocking tunneling nanotubes and Siglec-1 expression.

The paper shows HIV-1 Tat enhances Mtb and Toxoplasma growth by inhibiting clathrin-mediated endocytosis and autophagy through PI(4,5)P2 binding and palmitoylation.

The paper identifies RvD5-GPR32 signaling as a mechanism by which TB-PE reprograms macrophage metabolism to impair anti-tuberculous immunity.

The paper identifies a TUBB3+ cell population in TB granulomas across multiple species and patients, distinct from known cell types and present in other infections.

This study uses human airway organoids to model tuberculosis infection, showing mycobacteria infect epithelial cells with low efficiency and the organoid microenvironment controls but does not eliminate the pathogen.