Sylvaine Huc-Brandt

Verapamil limits inflammation by restoring VGCC-driven epithelial Ca2+ in models of cystic fibrosis

This study shows verapamil reduces inflammation in cystic fibrosis by normalizing epithelial calcium signaling and oxidative stress in zebrafish and human cells.

HIV-1 Tat favors the multiplication of Mycobacterium tuberculosis and toxoplasma by inhibiting clathrin-mediated endocytosis and autophagy

The paper shows HIV-1 Tat enhances Mtb and Toxoplasma growth by inhibiting clathrin-mediated endocytosis and autophagy through PI(4,5)P2 binding and palmitoylation.

The Staphylococcus aureus prophage-encoded SSBP attenuates virulence and enhances IL-6-mediated macrophage clearance

This study identifies a prophage-encoded SSBP that reduces S. aureus virulence and enhances macrophage-mediated bacterial clearance through IL-6 activation.

Achromobacter xylosoxidans modulates Pseudomonas aeruginosa virulence through a multi-target mechanism of competition

This study shows that Achromobacter xylosoxidans strain Ax 200 reduces Pseudomonas aeruginosa virulence in a zebrafish model through strain-dependent mechanisms affecting biofilm formation, motility, and iron acquisition.