Christel Vérollet

Dual human lung models reveal compartment-specific activity of anti-tuberculosis drugs and host-directed therapies

This study uses dual human lung models to evaluate anti-tuberculosis drugs and host-directed therapies, revealing compartment-specific efficacy and immune responses.

Inhibition of glycolysis in tuberculosis-mediated metabolic rewiring reduces HIV-1 spread across macrophages

This study shows that inhibiting glycolysis in TB-infected macrophages reduces HIV-1 spread by blocking tunneling nanotubes and Siglec-1 expression.

The tuberculosis-associated microenvironment promotes HIV-1 persistence by impairing CD8+ T cell-mediated viral control

This study investigates how the tuberculosis-associated microenvironment affects HIV-1 persistence by impairing CD8+ T cell-mediated viral control in coinfected individuals.

HIV-1 Tat favors the multiplication of Mycobacterium tuberculosis and toxoplasma by inhibiting clathrin-mediated endocytosis and autophagy

The paper shows HIV-1 Tat enhances Mtb and Toxoplasma growth by inhibiting clathrin-mediated endocytosis and autophagy through PI(4,5)P2 binding and palmitoylation.

Moesin controls cell-cell fusion and osteoclast function

This study identifies moesin's role in osteoclast fusion and function, showing its impact on bone resorption and disease therapy.

Lipid-mediated GPR32 signaling reprograms macrophage metabolism to impair anti-tuberculous immunity

The paper identifies RvD5-GPR32 signaling as a mechanism by which TB-PE reprograms macrophage metabolism to impair anti-tuberculous immunity.

Identification of a unique TUBB3+ cell population in the tuberculosis granuloma

The paper identifies a TUBB3+ cell population in TB granulomas across multiple species and patients, distinct from known cell types and present in other infections.

Loss of ninein interferes with osteoclast formation and causes premature ossification

This study shows that ninein deficiency impairs osteoclast formation and bone resorption, leading to premature ossification and altered skeletal development.