Author

Bruno D. Beaumelle

Centre National de la Recherche ScientifiqueORCID 0000-0002-4912-9134Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 2 Organism:mouse· 1 Assay:proteomics· 1 Organism:zebrafish· 1

Frequent Co-Authors

Maxime JanseniD· 3 shared Aurélie Rivault· 2 shared Laurent ChaloiniD· 2 shared Alain MakinsoniD· 1 shared Angeline Tellier· 1 shared Anne‐Béatrice Blanc‐PotardiD· 1 shared Audrey BernutiD· 1 shared Célia Bouhnik· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersMicrobiology

Maxime JansenORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A new HIV-1 latency reversing agent activating HIV-Tat

Phuoc Bao Viet Tong, Laetitia Marty, Nawel Chekrit, Martine Pugnière, Jean‐Marie Péloponèse, Célia Bouhnik, Édouard Tuaillon, Alain Makinson, Laurent Chaloin, Bruno D. Beaumelle

This paper introduces a new HIV-1 latency reversing agent, D10, which activates HIV-1 Tat to induce viral production from latent cells.

bioRxiv · Aug 21, 2026 · PreprintMicrobiology

HIV-1 Tat protects macrophages from killing by the Exoenzyme U from Pseudomonas aeruginosa

Maxime Jansen, Aurélie Rivault, Angeline Tellier, Lise Chauveau, Anne‐Béatrice Blanc‐Potard, Bruno D. Beaumelle

This paper shows HIV-1 Tat protects macrophages from ExoU-mediated toxicity by interfering with ExoU recruitment to PI(4,5)P2, while also enhancing toxicity of ExoU-deficient PAE.

bioRxiv · Jun 18, 2026 · PreprintMicrobiology

Syk activation during FcγR-mediated phagocytosis involves Syk palmitoylation and desulfenylation

Maxime Jansen, Jean‐Marc Strub, Laurent Chaloin, Peter J. P. Coopman, Bruno D. Beaumelle

This study identifies Syk palmitoylation and desulfenylation as critical for FcγR-mediated phagocytosis by regulating Syk localization, activation, and downstream signaling.

Life Science Alliance · Jan 14, 2026Peer-reviewedCell Biology

HIV-1 Tat favors the multiplication of Mycobacterium tuberculosis and toxoplasma by inhibiting clathrin-mediated endocytosis and autophagy

Aurélie Rivault, Audrey Bernut, Myriam Ben-Neji, Magali Abrantes, Maxime Jansen, Sylvaine Huc-Brandt, Sébastien Besteiro, Yann Bordat, Mai Nguyen Chi, Nelly Audemard, Margaux Mesleard-Roux, David Perrais, Olivier Neyrolles, Geanncarlo Lugo‐Villarino, Christel Vérollet, , Bruno D. Beaumelle

The paper shows HIV-1 Tat enhances Mtb and Toxoplasma growth by inhibiting clathrin-mediated endocytosis and autophagy through PI(4,5)P2 binding and palmitoylation.

PLoS Pathogens · Sep 11, 2025Peer-reviewedMicrobiology