Longitudinal Multi-omic Immune Profiling Reveals Age-Related Immune Cell Dynamics in Healthy Adults
Qiuyu Gong, Mehul Sharma, Marla C. Glass, Emma Lo Kuan, Aishwarya Chander, Mansi Singh, Lucas T. Graybuck, Zachary Thomson, Christian M. LaFrance, Samir Rachid Zaim, Tao Peng, Lauren Y. Okada, Palak C. Genge, Katherine E. Henderson, Elisabeth M. Dornisch, , Claire E. Gustafson
This study uses multi-omic profiling to analyze immune cell dynamics in healthy adults over time, finding age-related transcriptional changes in T cells and impaired memory B cell responses in older adults.
Nature · Oct 29, 2025Peer-reviewedImmunology