Zachary Thomson

The paper identifies diverse human antibody-secreting cell subsets using multi-omic methods and shows their distinct functional and spatial characteristics.

This study shows how multiple myeloma and its treatment alter the bone marrow niche, impairing immune reconstitution and vaccine responses, with mRNA vaccines showing better efficacy than influenza vaccines.

This study uses multi-omic profiling to analyze immune cell dynamics in healthy adults over time, finding age-related transcriptional changes in T cells and impaired memory B cell responses in older adults.

REFLEX enables scalable, multiomic T cell profiling with TCR sequencing, identifying novel CMV-reactive clonotypes in over 1.4 million T cells.

The paper identifies immune alterations preceding rheumatoid arthritis onset and provides tools for dataset exploration.

CryoSCAPE enables scalable immune profiling using cryopreserved whole blood for multi-omic single cell and functional assays, demonstrating compatibility with high-throughput RNA sequencing and functional testing.

This study maps the spatial and single-cell transcriptional landscape of human cerebellar development, revealing cell-type-specific gene expression and implications for neurological disorders.