STING_IFN_CH25H lipid axis links innate immune activation to tau pathology
Hao Chen, Li Fan, Man Ying Wong, Yohannes A. Ambaw, Jingjie Zhu, Kendra Norman, Pearly Ye, Nessa Foxe, Daphne Zhu, Yuansong Wan, Mahalashmi Srinivasan, Sue-Ann Mok, Laura Beth J McIntire, Tobias C. Walther, Robert V. Farese, , Wenjie Luo
The paper identifies a STING-IFN-CH25H lipid axis linking innate immune activation to tau pathology and shows its role in neurodegeneration.
bioRxiv · Dec 18, 2025 · PreprintNeuroscience