Jingjie Zhu

This study identifies TRAPPC8 as a brake on UFMylation that suppresses tauopathy by interacting with UBA5, showing its therapeutic potential in Alzheimer's disease.

The paper identifies a microglial gene program linked to dyskinesia in Parkinson's disease and shows that sTREM2 reduces dyskinesia by modulating TrkB signaling and synaptic plasticity.

The paper develops a neuron-specific interactome map in human excitatory neurons to identify novel risk genes and pathways in Alzheimer's disease.

This study identifies cGAS as a key mediator of TDP-43 pathology in ALS and shows that its inhibition reduces RNA splicing defects and neurodegeneration.

This study identifies cGAS-mediated IFN-I signaling as a driver of disease progression in drug-refractory epilepsy, showing that targeting cGAS reduces epileptic phenotypes and inflammation.

This study identifies soluble DLK1 from senescent microglia as a factor impairing oligodendrocyte function and altering neuronal activity in aging.

The paper identifies a STING-IFN-CH25H lipid axis linking innate immune activation to tau pathology and shows its role in neurodegeneration.

This study shows that DAP12 deficiency reduces tau-induced inflammation and myelin loss in mice, despite increased tau pathology, by altering microglia-oligodendrocyte interactions.

The R136S mutation on APOE3 enhances resistance to tau-related pathology and toxicity by downregulating the cGAS-STING-IFN signaling pathway.

The paper identifies sex-biased transcriptomic responses in aged demyelination, showing Tlr7 mediates these differences through interactions with sex chromosomes and gonads.