Author

Li Gan

Weill Cornell Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

Click to filter author papers

Neuroscience· 6 Systems Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 7 Research Focus:cell type annotation· 5 Research Focus:differential expression· 5 Research Focus:gene regulatory network inference· 5 Organism:human· 5 Organism:mouse· 5 Assay:spatial transcriptomics· 3 Assay:bulk RNA-seq· 2

Frequent Co-Authors

Jingjie ZhuiD· 3 shared Man Ying WongiD· 3 shared Pearly Ye· 3 shared Wenjie LuoiD· 3 shared Yuansong WaniD· 3 shared Anna G. OrriD· 2 shared Daphne Zhu· 2 shared Fred H. GageiD· 2 shared

Activity by Year

2020-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersNeuroscience

Jingjie ZhuORCID

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Cytoplasmic DNA Sensing Links LINE-1 Expression to Neuronal Senescence in Alzheimer's Disease

Joseph R. Herdy, Emma E Taylor, Lukas Karbacher, Oliver Borgogno, Larissa Traxler, Jessica Lagerwall, Vincent A. Huynh, Zornitsa V Lefterova, Austin Kang, Carlota Tosat‐Bitrián, Maxfield M. G. Kelsey, John M. Sedivy, Subhash C. Sinha, Li Gan, C. Frank Bennett, , Fred H. Gage

This study identifies LINE-1 retrotransposons as drivers of neuronal senescence in Alzheimer's disease through cytoplasmic DNA sensing and the cGAS-STING pathway.

bioRxiv · Jul 28, 2026 · PreprintNeuroscience

Humanized tauopathy chimeras uncover microglial and lncRNA strategies for neuroprotection

Wenhui Qu, Feng Li, Minwoo Wendy Jang, Pearly Ye, Ethan Cordes, Abulimiti Aikedan, Wen Hu, Ravi Kumar Nagiri, Man Ying Wong, Wenjie Luo, Mathew M. Blurton-Jones, Hagen Tilgner, Anna G. Orr, Shiaoching Gong, Li Gan

The paper develops a humanized neuroimmune model to study tauopathy and identifies microglial and lncRNA mechanisms that protect neurons.

bioRxiv · Jul 3, 2026 · PreprintNeuroscience

Microglial sTREM2 limits dyskinesia and acts on TrkB to support circuit plasticity

Caitlin Castagnola, Roberta Marongiu, Yuansong Wan, Eileen Ruth Torres, Li Fan, Minwoo Wendy Jang, Qiaoling Cui, Jihye Kim, Pearly Ye, Jingjie Zhu, Alisa Panichkina, Alexandra B. Fall, Kendra Norman, Beichen Gao, Nessa R. Foxe, , Li Gan

The paper identifies a microglial gene program linked to dyskinesia in Parkinson's disease and shows that sTREM2 reduces dyskinesia by modulating TrkB signaling and synaptic plasticity.

bioRxiv · May 7, 2026 · PreprintNeuroscience

Interactome mapping in human excitatory neurons reveals novel risk genes and pathways in Alzheimer's disease

Xiaomu Wei, Katie Munechika, Yu Sun, Yuansong Wan, Tianyu Xia, Yuan Hou, Wenqiang Song, Kumar Yugandhar, Yiwen Wang, Se-In Lee, Zhengdong Sha, Yadi Zhou, Weixi Feng, Jingjie Zhu, Y. S. Tang, , Haiyuan Yu

The paper develops a neuron-specific interactome map in human excitatory neurons to identify novel risk genes and pathways in Alzheimer's disease.

bioRxiv · Mar 16, 2026 · PreprintSystems Biology

STING_IFN_CH25H lipid axis links innate immune activation to tau pathology

Hao Chen, Li Fan, Man Ying Wong, Yohannes A. Ambaw, Jingjie Zhu, Kendra Norman, Pearly Ye, Nessa Foxe, Daphne Zhu, Yuansong Wan, Mahalashmi Srinivasan, Sue-Ann Mok, Laura Beth J McIntire, Tobias C. Walther, Robert V. Farese, , Wenjie Luo

The paper identifies a STING-IFN-CH25H lipid axis linking innate immune activation to tau pathology and shows its role in neurodegeneration.

bioRxiv · Dec 18, 2025 · PreprintNeuroscience

GESIAP: A Versatile Genetically Encoded Sensor-based Image Analysis Program

Wenxi Zheng, Yajun Zhang, Roger E. Zhu, Peng Zhang, Smriti Nagpal Gupta, Limeng Huang, Deepika Sahoo, Kaiming Guo, Matthew E. Glover, Krishna C. Vadodaria, Mengyao Li, Tongrui Qian, Miao Jing, Jiesi Feng, Jinxia Wan, , Jie Zhu

GESIAP is a MATLAB-based image analysis program that processes genetically encoded sensor data to analyze neuromodulator transmission properties across cell types and species.

bioRxiv · Oct 5, 2022 · PreprintNeuroscience

A fast genetically encoded fluorescent sensor for faithful in vivo acetylcholine detection in mice, fish, worms and flies

Philip M. Borden, Peng Zhang, Amol V. Shivange, Jonathan S. Marvin, Joseph Cichon, Chuntao Dan, Kaspar Podgorski, António Manuel Pereira De Figueiredo, Ondřej Novák, Masashi Tanimoto, Eiji Shigetomi, Mark A. Lobas, Hyun-Tae Kim, Paula K. Zhu, Yajun Zhang, , Loren L. Looger

iAChSnFR, a fluorescent indicator built from a bacterial periplasmic binding protein, reports acetylcholine with large, fast signals in mouse, fish, fly and worm preparations.

bioRxiv · Feb 7, 2020 · PreprintNeuroscience