Li Fan

The paper shows how transient morphogenetic structures and stochastic innervation models shape reproducible yet flexible wiring in C. elegans nervous systems through a trade-off between physical constraints and molecular specificity.

This study shows that transplanting wild-type human iPSC-derived microglia into progranulin-deficient mice reduces neuropathology, circuit dysfunction, and behavioral issues in a FTD model.

The paper identifies a microglial gene program linked to dyskinesia in Parkinson's disease and shows that sTREM2 reduces dyskinesia by modulating TrkB signaling and synaptic plasticity.

This study identifies cGAS as a key mediator of TDP-43 pathology in ALS and shows that its inhibition reduces RNA splicing defects and neurodegeneration.

This study identifies cGAS-mediated IFN-I signaling as a driver of disease progression in drug-refractory epilepsy, showing that targeting cGAS reduces epileptic phenotypes and inflammation.

This study identifies soluble DLK1 from senescent microglia as a factor impairing oligodendrocyte function and altering neuronal activity in aging.

The paper identifies a STING-IFN-CH25H lipid axis linking innate immune activation to tau pathology and shows its role in neurodegeneration.

This study shows that DAP12 deficiency reduces tau-induced inflammation and myelin loss in mice, despite increased tau pathology, by altering microglia-oligodendrocyte interactions.

This study combines APOE4 and TREM2R47H in female tauopathy mice to identify pathways activated by AD risk factors, finding cGAS-STING signaling and microglial senescence as potential drivers.

The R136S mutation on APOE3 enhances resistance to tau-related pathology and toxicity by downregulating the cGAS-STING-IFN signaling pathway.

The paper creates a human iPSC model of 4R tauopathy and identifies genetic modifiers of Tau propagation using CRISPRi screening.

The paper introduces ScISOr-ATAC to measure splicing and chromatin accessibility in frozen brain tissues, finding convergent and divergent patterns in different cell types and conditions.

The paper identifies sex-biased transcriptomic responses in aged demyelination, showing Tlr7 mediates these differences through interactions with sex chromosomes and gonads.

This study shows that microglial NF-κB signaling drives tau spreading and toxicity in a mouse model of tauopathy, with inhibition reducing tau pathology and cognitive deficits.

The paper introduces SnISOr-Seq, a method for single-nuclei isoform RNA sequencing, and finds distinct combination patterns of transcript elements in human brain cell types.

The paper investigates how differential adhesion controls neurite placement in C. elegans brain neuropils through a retrograde zippering mechanism.

The paper identifies a Csf1r-independent microglial subset in adult mice that exhibits progenitor-like features and is distinct from homeostatic microglia.

This study shows that HMR-1/Cadherin mediates tissue cohesion during C. elegans neurulation, suggesting a potential homology with vertebrate neurulation.

This study identifies R47H-TREM2 mutation-induced proinflammatory microglial states in human AD and tauopathy mice, showing Akt pathway involvement and potential therapeutic targets.

The paper shows multicellular rosettes organize the nerve ring neuropil in C. elegans by guiding axon outgrowth and structural formation.

The paper shows that C. elegans amphid neurons form a multicellular rosette to collectively extend dendrites, using adhesion molecules and mechanical cues from surrounding tissues.