Author
Weill Cornell Medicine
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
8 papers
Recent·Most cited
Yuansong Wan, Ethan Cordes, Weixi Feng, Se-In Lee, Katie Munechika, Yu Sun, Zhisong Gao, Beichen Gao, Jingjie Zhu, Man Ying Wong, Kendra Norman, Siyu Wang, hao chen, Bangyan Liu, Zhong Li, , Li Gan
This study identifies TRAPPC8 as a brake on UFMylation that suppresses tauopathy by interacting with UBA5, showing its therapeutic potential in Alzheimer's disease.
bioRxiv · Aug 23, 2026 · PreprintNeuroscience
Caitlin Castagnola, Roberta Marongiu, Yuansong Wan, Eileen Ruth Torres, Li Fan, Minwoo Wendy Jang, Qiaoling Cui, Jihye Kim, Pearly Ye, Jingjie Zhu, Alisa Panichkina, Alexandra B. Fall, Kendra Norman, Beichen Gao, Nessa R. Foxe, , Li Gan
The paper identifies a microglial gene program linked to dyskinesia in Parkinson's disease and shows that sTREM2 reduces dyskinesia by modulating TrkB signaling and synaptic plasticity.
bioRxiv · May 7, 2026 · PreprintNeuroscience
Yajing Liu, Weixi Feng, Abulimiti Aikedan, Se-In Lee, Maitreyee Bhagwat, Ravi Kumar Nagiri, Man Ying Wong, Sadaf Amin, Wenhui Qu, Jingjie Zhu, Si-Yu Wang, Pearly Ye, Kendra Norman, Guillermo Coronas‐Samano, Marta Olah, , Li Gan
This study identifies cGAS as a key mediator of TDP-43 pathology in ALS and shows that its inhibition reduces RNA splicing defects and neurodegeneration.
bioRxiv · Feb 26, 2026 · PreprintNeuroscience
Yige Huang, Li Fan, Man Ying Wong, Zhuofan Lei, Balaji Krishnamachary, Daphne Zhu, Mika P. Cadiz, Ravi Kumar Nagiri, Pearly Ye, Kendra Norman, Maitreyee Bhagwat, Young Jae Lee, H LI, Jingjie Zhu, Sadaf Amin, , Li Gan
This study identifies cGAS-mediated IFN-I signaling as a driver of disease progression in drug-refractory epilepsy, showing that targeting cGAS reduces epileptic phenotypes and inflammation.
bioRxiv · Feb 2, 2026 · PreprintNeuroscience
Hao Chen, Li Fan, Man Ying Wong, Yohannes A. Ambaw, Jingjie Zhu, Kendra Norman, Pearly Ye, Nessa Foxe, Daphne Zhu, Yuansong Wan, Mahalashmi Srinivasan, Sue-Ann Mok, Laura Beth J McIntire, Tobias C. Walther, Robert V. Farese, , Wenjie Luo
The paper identifies a STING-IFN-CH25H lipid axis linking innate immune activation to tau pathology and shows its role in neurodegeneration.
bioRxiv · Dec 18, 2025 · PreprintNeuroscience
Gillian Carling, Li Fan, Nessa R. Foxe, Kendra Norman, Man Ying Wong, Daphne Zhu, Carlo Corona, Agnese Razzoli, Fangmin Yu, Allan Yarahmady, Pearly Ye, Hao Chen, Yige Huang, Sadaf Amin, Rebecca Sereda, , Li Gan
This study combines APOE4 and TREM2R47H in female tauopathy mice to identify pathways activated by AD risk factors, finding cGAS-STING signaling and microglial senescence as potential drivers.
Neuron · Sep 30, 2024Peer-reviewedNeuroscience
Sarah A. Naguib, Chloe Lopez-Lee, Eileen Ruth S. Torres, Se-In Lee, Jingjie Zhu, Daphne Zhu, Pearly Ye, Kendra Norman, Mingrui Zhao, Man Ying Wong, Yohannes A. Ambaw, Rodrigo Castaneda, Wei Wang, Tark Patel, Maitreyee Bhagwat, , Li Gan
The R136S mutation on APOE3 enhances resistance to tau-related pathology and toxicity by downregulating the cGAS-STING-IFN signaling pathway.
bioRxiv · Apr 25, 2024 · PreprintNeuroscience
Chloe Lopez-Lee, Lay Kodama, Li Fan, Man Ying Wong, Nessa R. Foxe, Laraib Jiaz, Fangmin Yu, Pearly Ye, Jingjie Zhu, Kendra Norman, Eileen Ruth S. Torres, Rachel D. Kim, Gergey Alzaem Mousa, Dena B. Dubal, Shane Antony Liddelow, , Li Gan
The paper identifies sex-biased transcriptomic responses in aged demyelination, showing Tlr7 mediates these differences through interactions with sex chromosomes and gonads.
bioRxiv · Sep 19, 2023 · PreprintNeuroscience