Molecular mechanisms of recruitment, function and regulation of UPF1 in histone mRNA decay
Alexandrina Machado de Amorim, Guangpu Xue, Theresa Dittmers, Wenxia He, Sarah Lewandowski, Cecilia Perez-Borrajero, Juliane Bethmann, Nevena Mateva, Clemens Krage, Vidhyadhar Nandana, Janosch Hennig, Henning Urlaub, William F. Marzluff, Sutapa Chakrabarti
This study identifies the molecular interactions of UPF1 in histone mRNA decay, showing how SLBP and UPF2 regulate its unwinding activity and degradation efficiency.
bioRxiv · Feb 23, 2025 · PreprintBiochemistry