William F. Marzluff

This study shows that Drosophila Mute represses histone mRNA outside S phase and differentially regulates histone gene expression during S phase, leading to developmental defects when disrupted.

The paper identifies NEPRO and C18ORF21 as constitutive subunits of metazoan RNase MRP, clarifying its composition and RNA binding specificity.

This study shows SUMO2 stabilizes HLB interactions and facilitates U7 snRNP assembly, preventing histone mRNA polyadenylation.

The paper investigates how cell cycle regulation controls transcriptional pausing of Drosophila replication-dependent histone genes, showing that Cyclin E/Cdk2 activation drives full-length transcript production during S phase.

This study identifies the molecular interactions of UPF1 in histone mRNA decay, showing how SLBP and UPF2 regulate its unwinding activity and degradation efficiency.

The paper identifies a 10 aa region in Drosophila SLBP essential for histone mRNA transcription in stage 10b oocytes, despite not being required for in vitro processing.

The paper introduces a single-cell analysis of Genome Architecture Mapping (GAM) data, revealing intercellular heterogeneity in 3D chromatin topology and developing a geometric model for nuclear structure.