Author

Thomas Lefeivre

University College DublinORCID 0009-0005-2689-8175Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alex von KriegsheimiD· 1 shared Alfonso Bolado‐CarrancioiD· 1 shared Anjan VenkateshiD· 1 shared Barbara De KegeliD· 1 shared Colm J. RyaniD· 1 shared Kieran J. WynneiD· 1 shared Niall Quinn· 1 shared Olivier DennleriD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperSystems Biology

Alex von KriegsheimORCID

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1 paper

Recent·Most cited

Systems BiologybioRxivPreprintSep 26, 2024

Paralog protein compensation preserves protein-protein interaction networks following gene loss in cancer

Anjan Venkatesh, Niall Quinn, Swathi Ramachandra Upadhya…·Colm J. Ryan

The paper shows that gene loss in cancer is often compensated by paralog protein abundance changes, stabilizing protein-protein interaction networks and creating therapeutic vulnerabilities.

1 citation

humanproteomics

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