Author

Nicholas R. Stec

University of Michigan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Annie J. Zalon· 2 shared Danielle M. DiFrancoiD· 2 shared Hayley S. McLoughliniD· 2 shared Kristen H. SchusteriD· 2 shared Yuanfang GuaniD· 2 shared Zaid Haque· 2 shared Alexandra F. PutkaiD· 1 shared Amanda M. Pierce· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersNeuroscience

Annie J. Zalon

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Author profile →

2 papers

Recent·Most cited

ASOs are an effective treatment for disease-associated oligodendrocyte signatures in premanifest and symptomatic SCA3 mice

Kristen H. Schuster, Annie J. Zalon, Danielle M. DiFranco, Alexandra F. Putka, Nicholas R. Stec, Sabrina I. Jarrah, Arsal Naeem, Zaid Haque, Hanrui Zhang, Yuanfang Guan, Hayley S. McLoughlin

This study shows that ASO treatment rescues oligodendrocyte dysfunction in SCA3 mice by targeting mutant ATXN3, suggesting potential for glial-targeted therapies in neurodegenerative diseases.

Molecular Therapy · Feb 29, 2024Peer-reviewedNeuroscience

Impaired oligodendrocyte maturation is an early feature in SCA3 disease pathogenesis

Kristen H. Schuster, Annie J. Zalon, Hongjiu Zhang, Danielle M. DiFranco, Nicholas R. Stec, Zaid Haque, Kate G. Blumenstein, Amanda M. Pierce, Yuanfang Guan, Henry Lauris Paulson, Hayley S. McLoughlin

This study identifies impaired oligodendrocyte maturation as an early feature in SCA3 disease pathogenesis through longitudinal transcriptomic analysis and functional validation in mice.

Journal of Neuroscience · Jan 18, 2022Peer-reviewedNeuroscience