Cellular Senescence Mediates Doxorubicin Chemotherapy-Induced Aortic Stiffening: Role of Glycation Stress
Ravinandan Venkatasubramanian, Mary Darrah, Sophia A. Mahoney, David A. Hutton, Grace S. Maurer, Katelyn R. Ludwig, Nicholas S. VanDongen, Nathan Greenberg, Abigail G. Longtine, Vienna Elizabeth Brunt, Parminder Pal Singh, James J. Galligan, Marissa N. Trujillo, Pankaj Kapahi, Simon Melov, , Zachary Stephen Clayton
This study shows that doxorubicin chemotherapy induces aortic stiffening via cellular senescence and the senescence-associated secretory phenotype, which can be mitigated by senolytic therapy.
Hypertension · Aug 1, 2025Peer-reviewedPhysiology