Author

David A. Hutton

University of Colorado BoulderORCID 0000-0002-5827-6953Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2

Frequent Co-Authors

Abigail G. LongtineiD· 2 shared Douglas R. SealsiD· 2 shared Judith CampisiiD· 2 shared Matthew J. RossmaniD· 2 shared Nathan GreenbergiD· 2 shared Nicholas S. VanDongen· 2 shared Ravinandan Venkatasubramanian· 2 shared Simon MeloviD· 2 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPhysiology

Abigail G. LongtineORCID

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2 papers

Recent·Most cited

Cellular Senescence Mediates Doxorubicin Chemotherapy-Induced Vascular Endothelial Dysfunction: Translational Evidence of Prevention with Senolytic Treatment

Ravinandan Venkatasubramanian, Sophia A. Mahoney, David A. Hutton, Nicholas S. VanDongen, Vienna Elizabeth Brunt, Nathan Greenberg, Abigail G. Longtine, Lukas Brandt, Andreas Beyer, Simon Melov, Judith Campisi, Matthew J. Rossman, Douglas R. Seals, Zachary Stephen Clayton

This study shows that cellular senescence contributes to Doxorubicin-induced vascular endothelial dysfunction and that senolytic treatment can prevent this dysfunction.

American Journal of Physiology-Heart and Circulatory Physiology · Oct 27, 2025Peer-reviewedPhysiology

Cellular Senescence Mediates Doxorubicin Chemotherapy-Induced Aortic Stiffening: Role of Glycation Stress

Ravinandan Venkatasubramanian, Mary Darrah, Sophia A. Mahoney, David A. Hutton, Grace S. Maurer, Katelyn R. Ludwig, Nicholas S. VanDongen, Nathan Greenberg, Abigail G. Longtine, Vienna Elizabeth Brunt, Parminder Pal Singh, James J. Galligan, Marissa N. Trujillo, Pankaj Kapahi, Simon Melov, , Zachary Stephen Clayton

This study shows that doxorubicin chemotherapy induces aortic stiffening via cellular senescence and the senescence-associated secretory phenotype, which can be mitigated by senolytic therapy.

Hypertension · Aug 1, 2025Peer-reviewedPhysiology