Author

Nicholas W. Barnes

Monash University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Andrew B. TobiniD· 1 shared Arthur ChristopoulosiD· 1 shared Ben CapuanoiD· 1 shared Céline ValantiD· 1 shared David M. ThaliD· 1 shared Denise L. WootteniD· 1 shared Emma T. van der WesthuizeniD· 1 shared Fu Xiao· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperPharmacology & Toxicology

Andrew B. TobinORCID

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1 paper

Recent·Most cited

Structural basis of MK-97 positive allosteric modulation at the M4 mAChR

Michaela G. Kaoullas, Jesse I. Mobbs, Ziva Vuckovic, Matthew J. Belousoff, Fu Xiao, Keya Joshi, Jinan Wang, Nicholas W. Barnes, Vi Pham, Mahmuda Yeasmin, Geoff V. Thompson, Emma T. van der Westhuizen, Manuela Jörg, Ben Capuano, Andrew B. Tobin, , David M. Thal

This paper reports the cryo-EM structure of the M4 mAChR bound to MK-97 and acetylcholine, revealing how MK-97's binding mode improves PAM activity through distributed interactions.

bioRxiv · May 11, 2026 · PreprintPharmacology & Toxicology