Matthew J. Belousoff

Structural basis of MK-97 positive allosteric modulation at the M4 mAChR

This paper reports the cryo-EM structure of the M4 mAChR bound to MK-97 and acetylcholine, revealing how MK-97's binding mode improves PAM activity through distributed interactions.

In vivo functional profiling and structural characterisation of the human Glp1r A316T variant

This study investigates the human Glp1r A316T variant's effects on glucose metabolism and GLP-1RA responses using mouse models and structural analyses.

Unconventional binding of Calmodulin to CHK2 kinase inhibits catalytic activity

The paper identifies an unconventional mechanism where Ca2+-CaM binds CHK2 kinase to inhibit its activity, contrasting with its typical role in promoting kinase activity.

A Versatile Antibody Capture System that Drives Precise In Vivo Delivery of mRNA loaded Lipid Nanoparticles and Enhances Gene Expression

This paper introduces an antibody capture system for LNPs that enhances mRNA delivery and gene expression by enabling precise targeting to T cells with minimal off-target effects.

De novo design of miniprotein agonists and antagonists targeting G protein-coupled receptors

This paper presents computational methods for designing GPCR-binding miniproteins and validates them through high-throughput screening, producing agonists and antagonists for multiple GPCRs.

Prolonged signaling of backbone-modified glucagon-like peptide-1 analogues with diverse receptor trafficking

This study identifies GLP-1 analogues with prolonged signaling by modifying specific amino acids, showing how receptor trafficking and peptide structure affect signaling duration.